The main objective of the nuclear medicine project is to develop a personalized dosimetry methodology for internal vectorized radiotherapy (IVRT). The radiotracer used in IVRT binds to the targeted tumor zone, but also to organs at risk. At present, a fixed dose is delivered. Imaging will make it possible to monitor and quantify, for each patient, the distribution of the radiotracer in the tumor target and in organs at risk, and to adapt the dose during treatment. Ultimately, the aim is to propose an individual dose tailored to each patient, in order to increase therapeutic efficacy through tumor dosimetry, and reduce side effects by limiting the dose to organs at risk.
Geometric model of a photon-counting digital PET scanner
![[18F]-DOPA PET imaging in neuro-oncology](https://iadi.univ-lorraine.fr/wp-content/uploads/2023/08/nuclearmed2-1_en.png)
[18F]-DOPA PET imaging in neuro-oncology
Collaborators
Nancyclotep
Selected papers
- In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human-derived glioblastoma cell lines. Clément A, Doyen M, Fauvelle F, Hossu G, Chen B, Barberi-Heyob M, Hirtz A, Stupar V, Lamiral Z, Pouget C, Gauchotte G, Karcher G, Beaumont M, Verger A, Lemasson B. NMR Biomed. 2021 Jun;34(6):e4490. doi: 10.1002/nbm.4490. Epub 2021 Feb 17.
- Monte Carlo simulation of digital photon counting PET. Salvadori J, Labour J, Odille F, Marie PY, Badel JN, Imbert L, Sarrut D. EJNMMI Phys. 2020 Apr 25;7(1):23. doi: 10.1186/s40658-020-00288-w.
- Use of static and dynamic [18F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression. Zaragori T, Ginet M, Marie PY, Roch V, Grignon R, Gauchotte G, Rech F, Blonski M, Lamiral Z, Taillandier L, Imbert L, Verger A. EJNMMI Res. 2020 May 29;10(1):56. doi: 10.1186/s13550-020-00645.